Project A3

2024

Metabolic rewiring promotes anti-inflammatory effects of glucocorticoids

Jean-Philippe Auger, Max Zimmermann, Maria Faas, Ulrich Stifel, David Chambers, Brenda Krishnacoumar, R Verena Taudte, Charlotte Grund, Gitta Erdmann, Carina Scholtysek, Stefan Uderhardt, Oumaima Ben Brahim, Mónica Pascual Maté, Cornelia Stoll, Martin Böttcher, Katrin Palumbo-Zerr, Matthew S J Mangan, Maria Dzamukova, Markus Kieler, Melanie Hofmann, Stephan Blüml, Gernot Schabbauer, Dimitrios Mougiakakos, Uwe Sonnewald, Fabian Hartmann, David Simon, Arnd Kleyer, Anika Grüneboom, Susetta Finotto, Eicke Latz, Jörg Hofmann, Georg Schett, Jan Tuckermann, Gerhard Krönke

CD19 CAR T-Cell Therapy in Autoimmune Disease – A Case Series with Follow-up

Fabian Müller, Jule Taubmann, Laura Bucci, Artur Wilhelm, Christina Bergmann, Simon Völkl, Michael Aigner, Tobias Rothe, Ioanna Minopoulou, Carlo Tur, Johannes Knitza, Soraya Kharboutli, Sascha Kretschmann, Ingrid Vasova, Silvia Spoerl, Hannah Reimann, Luis Munoz, Roman G Gerlach, Simon Schäfer, Ricardo Grieshaber-Bouyer, Anne-Sophie Korganow, Dominique Farge-Bancel, Dimitrios Mougiakakos, Aline Bozec, Thomas Winkler, Gerhard Krönke, Andreas Mackensen, Georg Schett

2023:

Stunning of neutrophils accounts for the anti-inflammatory effects of clodronate liposomes

Stephan Culemann, Katharina Knab, Maximilien Euler, Anja Wegner, Hilal Garibagaoglu, Jochen Ackermann, Kim Fischer, Deborah Kienhöfer, Georgiana Crainiciuc, Jonas Hahn, Anika Grüneboom, Falk Nimmerjahn, Stefan Uderhardt, Andrés Hidalgo, Georg Schett, Markus H Hoffmann, Gerhard Krönke

2023:

An AI-Powered Clinical Decision Support System to Predict Flares in Rheumatoid Arthritis: A Pilot Study

Hannah Labinsky, Dubravka Ukalovic, Fabian Hartmann, Vanessa Runft, André Wichmann, Jan Jakubcik, Kira Gambel, Katharina Otani, Harriet Morf, Jule Taubmann, Filippo Fagni, Arnd Kleyer, David Simon, Georg Schett, Matthias Reichert and Johannes Knitza

2022:

Anti-CD19 CAR T cell therapy for refractory systemic lupus erythematosus

Andreas Mackensen, Fabian Müller, Dimitrios Mougiakakos, Sebastian Böltz, Artur Wilhelm, Michael Aigner, Simon Völkl, David Simon, Arnd Kleyer, Luis Munoz, Sascha Kretschmann, Soraya Kharboutli, Regina Gary, Hannah Reimann, Wolf Rösler, Stefan Uderhardt, Holger Bang, Martin Herrmann, Arif Bülent Ekici, Christian Buettner, Katharina Maria Habenicht, Thomas H Winkler, Gerhard Krönke, Georg Schett

Comparison of physician and artificial intelligence-based symptom checker diagnostic accuracy

Markus Gräf, Johannes Knitza, Jan Leipe, Martin Krusche, Martin Welcker, Sebastian Kuhn, Johanna Mucke, Axel J Hueber, Johannes Hornig, Philipp Klemm, Stefan Kleinert, Peer Aries, Nicolas Vuillerme, David Simon, Arnd Kleyer, Georg Schett, Johanna Callhoff

Remote self-collection of capillary blood using upper arm devices for autoantibody analysis in patients with immune-mediated inflammatory rheumatic diseases

Joshua Zarbl, Ekaterina Eimer, Camilla Gigg, Gerlinde Bendzuck, Marianne Korinth, Corinna Elling-Audersch, Arnd Kleyer, David Simon, Sebastian Boeltz, Martin Krusche, Johanna Mucke, Felix Muehlensiepen, Nicolas Vuillerme, Gerhard Krönke, Georg Schett, Johannes Knitza

Intensity and longevity of SARS-CoV-2 vaccination response in patients with immune-mediated inflammatory disease: a prospective cohort study

David Simon, Koray Tascilar, Filippo Fagni, Arnd Kleyer, Gerhard Krönke, Christine Meder, Peter Dietrich, Till Orlemann, Johanna Mößner, Jule Taubmann, Melek Yalcin Mutlu, Johannes Knitza, Stephan Kemenes, Anna-Maria Liphardt, Verena Schönau, Daniela Bohr, Louis Schuster, Fabian Hartmann, Ioanna Minopoulou, Moritz Leppkes, Andreas Ramming, Milena Pachowsky, Florian Schuch, Monika Ronneberger, Stefan Kleinert, Axel J Hueber, Karin Manger, Bernhard Manger, Raja Atreya, Carola Berking, Michael Sticherling, Markus F Neurath, Georg Schett

Machine learning-based improvement of an online rheumatology referral and triage system

Johannes Knitza, Lena Janousek, Felix Kluge, Cay Benedikt von der Decken, Stefan Kleinert, Wolfgang Vorbrüggen, Arnd Kleyer, David Simon, Axel J Hueber, Felix Muehlensiepen, Nicolas Vuillerme, Georg Schett, Bjoern M Eskofier, Martin Welcker, Peter Bartz-Bazzanella

Microbiota-Derived Propionate Modulates Megakaryopoiesis and Platelet Function

Kerstin Dürholz, Eva Schmid, Michael Frech, Vugar Azizov, Nadine Otterbein, Sébastien Lucas, Manfred Rauh, Georg Schett, Heiko Bruns, Mario M Zaiss

Non-invasive metabolic profiling of inflammation in joints and entheses by multispectral optoacoustic tomography

Koray Tascilar, Filippo Fagni, Arnd Kleyer, Sara Bayat, Robert Heidemann, Florian Steiger, Gerhard Krönke, Daniela Bohr, Andreas Ramming, Fabian Hartmann, Daniel Klett, Anna Federle, Adrian P Regensburger, Alexandra L Wagner, Ferdinand Knieling, Markus F Neurath, Georg Schett, Maximilian Waldner, David Simon

Accuracy and tolerability of self-sampling of capillary blood for analysis of inflammation and autoantibodies in rheumatoid arthritis patients-results from a randomized controlled trial

Johannes Knitza, Koray Tascilar, Nicolas Vuillerme, Ekaterina Eimer, Paul Matusewicz, Giulia Corte, Louis Schuster, Timothée Aubourg, Gerlinde Bendzuck, Marianne Korinth, Corinna Elling-Audersch , Arnd Kleyer, Sebastian Boeltz, Axel J Hueber, Gerhard Krönke, Georg Schett, David Simon

TELERA—Asynchronous TELEmedicine for Patients With Rheumatoid Arthritis: Study Protocol for a Prospective, Multi-Center, Randomized Controlled Trial

Johanna Mucke, Johannes Knitza, Felix Muehlensiepen, Manuel Grahammer, Ramona Stenzel, David Simon, Arnd Kleyer, Gerhard Krönke, Charlotte Sharp, Gerlinde Bendzuck, Marianne Korinth, Corinna Elling-Audersch, Nicolas Vuillerme, Georg Schett, Ann-Christin Pecherand, Martin Krusche

IgA Complexes Induce Neutrophil Extracellular Trap Formation More Potently Than IgG Complexes

Anna-Katharina Gimpel, Antonio Maccataio, Harald Unterweger, Maria V. Sokolova, Georg Schett and Ulrike Steffen

2021:

IL-33-induced metabolic reprogramming controls the differentiation of alternatively activated macrophages and the resolution of inflammation

Maria Faas, Natacha Ipseiz, Jochen Ackermann, Stephan Culemann, Anika Grüneboom, Fenja Schröder, Tobias Rothe, Carina Scholtysek, Martin Eberhardt, Martin Böttcher, Philipp Kirchner, Cornelia Stoll, Arif Ekici, Maximilian Fuchs, Meik Kunz, Benno Weigmann, Stefan Wirtz, Roland Lang, Joerg Hofmann, Julio Vera, David Voehringer, Alessandro Michelucci, Dimitrios Mougiakakos, Stefan Uderhardt, Georg Schett, Gerhard Krönke

IgA anti-citrullinated protein antibodies (IgA ACPA) are associated with flares during DMARD tapering in rheumatoid arthritis

Maria V Sokolova, Melanie Hagen, Holger Bang, Georg Schett, Juergen Rech, Ulrike Steffen, RETRO study group.

Autoantibodies in Rheumatoid Arthritis: Historical Background and Novel Findings

Maria V Sokolova, Georg Schett, Ulrike Steffen

CD19-Targeted CAR T Cells in Refractory Systemic Lupus Erythematosus

Dimitrios Mougiakakos, Gerhard Krönke, Simon Völkl, Sascha Kretschmann, Michael Aigner, Soraya Kharboutli, Sebastian Böltz, Bernhard Manger, Andreas Mackensen, Georg Schett

Vugar Azizov, Mario M Zaiss

2020:

COVID-19 revisiting inflammatory pathways of arthritis

Schett G, Manger B, Simon D, Caporali R.

COVID-19: risk for cytokine targeting in chronic inflammatory diseases?

Azizov V, Dietel K, Steffen F, Dürholz K, Meidenbauer J, Lucas S, Frech M, Omata Y, Tajik N, Knipfer L, Kolenbrander A, Seubert S, Lapuente D, Sokolova MV, Hofmann J, Tenbusch M, Ramming A, Steffen U, Nimmerjahn F, Linker R, Wirtz S, Herrmann M, Temchura V, Sarter K, Schett G, Zaiss MM

A set of serum markers detecting systemic inflammation in psoriatic skin, entheseal, and joint disease in the absence of C-reactive protein and its link to clinical disease manifestations

Sokolova MV, Simon D2, Nas K, Zaiss MM, Luo Y, Zhao Y, Rech J, Schett G

2019: Neutrophil Extracellular Traps Initiate Gallstone Formation

Luis E Muñoz, Sebastian Boeltz, Rostyslav Bilyy, Christine Schauer, Aparna Mahajan, Navena Widulin, Anika Grüneboom, Irmgard Herrmann, Edgyda Boada, Manfred Rauh, Veit Krenn, Mona H C Biermann , Malgorzata J Podolska, Jonas Hahn, Jasmin Knopf, Christian Maueröder, Solomiya Paryzhak, Tetiana Dumych, Yi Zhao, Markus F Neurath, Markus H Hoffmann, Tobias A Fuchs, Moritz Leppkes, Georg Schett, Martin Herrmann

The Role of Dietary Fiber in Rheumatoid Arthritis Patients: A Feasibility Study

Häger J, Bang H, Hagen M, Frech M, Träger P, Sokolova MV, Steffen U, Tascilar K, Sarter K, Schett G, Rech J, Zaiss MM

How Autoantibodies Regulate Osteoclast Induced Bone Loss in Rheumatoid Arthritis

Ulrike Steffen, Georg Schett, and Aline Bozec